Study
This research tested how BPC 157, a stomach peptide, affects acute pancreatitis in rats. The study found BPC 157 helped reduce pancreas inflammation and prevent organ damage. The peptide worked by improving blood flow and reducing swelling in multiple organs including the brain, heart, lungs, liver and kidneys. BPC 157 was effective both when given immediately after injury and when treatment was delayed.
The study shows BPC 157 could be a potential treatment for acute pancreatitis and its complications. However, this research was done on rats, so human trials would be needed before any medical recommendations can be made.
Research Methods
The researchers:
- Used rats with induced acute pancreatitis through bile duct ligation
- Tested two doses of BPC 157 (10 μg/kg and 10 ng/kg)
- Administered BPC 157 in two ways: immediately after injury and delayed treatment
- Measured blood pressure, organ swelling, tissue damage
- Examined tissue samples under microscope
- Tracked changes over different time periods (30 min, 5 hours, 24 hours)
- Compared results between treated and untreated groups
Publication Details
- Title: Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats
- Researchers: Igor Petrovic, Luka Kalogjera, Hrvoje Vranes, et al.
- Publication: Biomedicines
- Publication date: 2022
- PMID: 35740321
- DOI: 10.3390/biomedicines10061299
- Source URL: https://pubmed.ncbi.nlm.nih.gov/35740321/