💉 BPC-157

BPC 157 Peptide Shows Promise in Treating Acute Pancreatitis

2 min read

Study

This research examined how a peptide called BPC 157 affects acute pancreatitis in rats. The researchers focused on understanding how this peptide impacts blood vessel function and organ protection when the bile duct is blocked.

The study found that BPC 157 helped reduce pancreas inflammation and damage in rats with blocked bile ducts. The peptide worked by improving blood flow through alternative pathways, particularly through a blood vessel called the azygos vein. This helped maintain proper blood circulation when other major blood vessels were compromised.

The researchers tested different doses of BPC 157 (10 μg/kg and 10 ng/kg) given either through the stomach or orally. They found both early treatment and delayed treatment showed positive effects. The peptide helped prevent or reduce various complications including brain swelling, heart problems, lung damage, and liver and kidney issues.

The results indicate that BPC 157 may have potential therapeutic applications for acute pancreatitis and related complications. The peptide appears to work by helping maintain proper blood flow and reducing inflammation across multiple organ systems.

Research Methods

The study used rats as test subjects and created acute pancreatitis by ligating (tying off) their bile ducts. The researchers divided the experiments into different time periods:

  • Short-term: 0-30 minutes
  • Medium-term: 0-5 hours
  • Long-term: 0-24 hours

They tested two different treatment approaches:

  1. Early treatment: BPC 157 given immediately after bile duct ligation
  2. Delayed treatment: BPC 157 given at 4.5 hours or 5 hours after ligation

The researchers measured multiple parameters including:

  • Blood pressure in various blood vessels
  • Blood flow patterns
  • Organ swelling
  • Tissue damage through microscopic examination
  • Blood tests for pancreatic enzymes
  • Heart function
  • Inflammatory markers

Publication Details

  • Title: Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats
  • Researchers: Igor Petrovic, Luka Kalogjera, Hrvoje Vranes, and team
  • Publication: Biomedicines
  • Publication date: June 2022
  • PMID: 35740321
  • DOI: 10.3390/biomedicines10061299
  • Source URL: https://pubmed.ncbi.nlm.nih.gov/35740321/

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