Study
This research examined how BPC 157, a peptide made of 15 amino acids found in human stomach fluid, helps tendons heal. The study found that BPC 157 makes tendon cells grow faster and helps them survive under stress conditions. The peptide also helps tendon cells move and spread across surfaces, which supports the healing process.
The research showed that BPC 157 works by activating specific proteins called FAK and paxillin inside cells. When these proteins become activated, they help cells move and survive. This explains why BPC 157 has shown positive results in previous studies where it helped heal injured tendons.
The findings suggest that BPC 157 could be useful for treating tendon injuries. The peptide helps tendon cells survive difficult conditions and promotes their movement to injured areas. These effects combine to support the natural healing process of damaged tendons.
Research Methods
The researchers conducted several laboratory experiments using rat tendon cells:
They took pieces of tendon and grew them in dishes with and without BPC 157 to measure cell growth. They tested how well tendon cells survived when exposed to hydrogen peroxide stress. The team measured cell movement using special filters that allowed them to count how many cells moved through them. They examined how cells spread on surfaces and looked at the formation of internal cell structures. They analyzed protein activation by measuring phosphorylation levels of FAK and paxillin proteins.
Publication Details
- Title: The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration
- Researchers: Chung-Hsun Chang et al.
- Publication: Journal of Applied Physiology
- Publication date: March 2011
- PMID: 21030672
- DOI: 10.1152/japplphysiol.00945.2010
- Source URL: https://pubmed.ncbi.nlm.nih.gov/21030672/